Faculty

Chris Burns, PhD

Associate Professor of Biomedical Sciences
Molecular, Cellular, and Developmental Biology

Recent Publications

  • Burns CM, McCormack WT, Wragg S. TBL Oversight for Continuous Quality Improvement and Acceptance. Medical Science Educator 2014;24:215-217.DOI:10.1007/s40670-014-0033-2.
  • Yoon MH, Burns CM, Michaelsen VE. Team-Based Learning in Different Classroom Settings. Medical Science Educator 2014;24:157-160. DOI: 10.1007/s40670-014-0024-3.
  • Burns CM. Promoting Science Through Interprofessional Education. Medical Science Educator 2013;23(3S):403-4. DOI: 10.1007/BF03341655.
  • McCollum MA, Chapin A, Burns CM, Pearson CM. Rewarding Collaborative Learning Skills in the Pre-clerkship Curriculum. Medical Education 2013;47:1135. DOI: 10.1111/medu.12333.

 

Ron Fiscus, PhD

Molecular Physiology/Pharmacology

Active research

  • Molecular Pathology and Pharmacology with special interest in diabetes, obesity, Alzheimer’s and Parkinson’s disease and various cancers
  • Developing new therapeutic strategies to target specific isoforms/splice variants and subcellular localization of protein kinases and phosphatases Gene knockdown and ultrasensitive imaging to identify previously- unrecognized kinases/phosphatases involved in pathology of diabetes/obesity, Alzheimer’s/Parkinson’s disease and cancers.
  • Identifying novel biomarkers for early diagnosis of fatty liver disease, Alzheimer’s and Parkinson’s, diabetes and cancer.

Recent publications

  • Castanino, B.F.B. and R.R. Fiscus (2016)  Simultaneous quantification of protein kinase C (PKC) and protein kinase G (PKG) catalytic activities in biological samples by a novel near-infrared-fluorescence (NIRF)-based methodology utilizing combinations of selective PKC inhibitors. (submitted).
  • Johlfs, M.G. and R.R. FISCUS. (2016) Direct serine-17 phosphorylation of c-Src by protein kinase G type-I??as a cellular mechanism mediating anti-apoptotic and growth-stimulatory effects in human NCI-H23 non-small cell lung cancer cells. (submitted).
  • Wong, J.C. and R.R. FISCUS.  (2015)  Resveratrol at anti-angiogenesis/anti-cancer concentrations suppresses protein kinase G signaling and decreases IAPs expression in HUVECs.  AntiCancer Research  35: 273-282.
  • Johlfs, M.G., Gorjala, P., Urasaki, Y., Le, T.T. and R.R. FISCUS. (2015)  Capillary isoelectric focusing immunoassay for fat cell differentiation proteomics.  PLoS ONE 10(7):e0132105.

Ken Rosenthal, PhD

Professor of Biomedical Sciences
Biochemistry, Tumor Virology

Recent Publications

  • Stone, S., Edmonds, R., Rosenthal, K.S., 2013. Probiotics: Helping out the normal flora. Inf Dis Clin Prac. 21: 305-311.
  • K.S. Rosenthal et al. 2015. Future rheumatoid arthritis (RA) vaccine therapies: lessons from therapeutic L.E.A.P.S.TM vaccines for models of RA. Exp. Rev Vaccines. 14:  891-908.
  • K.S. Rosenthal, J. Sikon, A. Kuntz. Why Don’t We Have a Vaccine Against……….?  Part 1. Viruses.   Infect Dis Clin Pract 2015;23: 202–210.
  • Basic Virology, in, Practical Handbook of Microbiology, Third Edition. 2015. edited by Lawrence Green, Taylor and Francis.
  • Medical microbiology, 8th edition,  (2016). Ed., Murray, Rosenthal and Pfaller, Elsevier, Philadelphia, (Author and Editor, Basic Microbiology, Immunology and Virology Sections.

Research Interests

  • Development and study of LEAPS vaccines for HSV, Breast Cancer, Rheumatoid Arthritis and other diseases.
  • The interaction of herpes simplex virus (HSV) with its host leading to disease and immunity.
  • Study of the biochemistry and cell biology of HSV glycoprotein synthesis, virion assembly and release.
  • Study of the ICP34.5 gene and protein and its contribution to neuroinvasive disease (encephalitis).
  • Study of the mode of action of the antiviral drugs, tromantadine and D609.
  • Use of flow cytometry in cell biological and immunological analysis.
  • Development of a polymer membrane device for transplantation and immunoisolation of porcine islet cells for treatment of Type I diabetes.


Tim Le, PhD

Assistant Professor of Biomedical Sciences
Biochemistry and Molecular Biology, Biomedical Engineering

Active research

  • Targeting lipid droplet for diagnosis and therapy of cancer and metabolic diseases.

Recent publications

  • Mitra R, Goodman OB, Le TT, Enhanced detection of metastatic prostate cancer cells in human plasma with lipid bodies staining. BMC Cancer 14:91 (2014). PMID: 24528787.
  • Le TT, Urasaki Y, Pizzorno G. Uridine prevents tamoxifen-induced liver lipid droplet accumulation. BMC Pharmacology & Toxicology 15:27 (2014). PMID: 24887406.
  • Urasaki Y, Pizzorno G, Le TT. Uridine affects liver protein glycosylation, insulin signaling, and heme biosynthesis. PLoS ONE 9(6):e99728 (2014). PMID: 24918436.
  • Johlfs M, Gorjala P, Urasaki Y, Le TT, Fiscus RR Capillary isoelectric focusing immunoassay for fat cell differentiation proteomics. PLoS ONE 10(7):e0132105 (2015).

More about Dr. Tim Le

Aurelio Lorico, MD, PhD

Associate Professor of Biomedical Sciences and Co-Director, Cancer Research Center

Active research

  • Experimental Oncology

Recent publications

  • Setti, M. et al. Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth. Oncotarget 6, 31413-31427 (2015).
  • Rappa, G., Green, T.M., Karbanova, J., Corbeil, D. & Lorico, A. Tetraspanin CD9 determines invasiveness and tumorigenicity of human breast cancer cells. Oncotarget 6, 7970-7991 (2015).
  • Rappa, G., Fargeas, C.A., Le, T.T., Corbeil, D. & Lorico, A. Letter to the editor: An intriguing relationship between lipid droplets, cholesterol-binding protein CD133 and Wnt/beta-catenin signaling pathway in carcinogenesis. Stem Cells 33, 1366-1370 (2015).
  • Rappa, G., Anzanello, F. & Lorico, A. Ethanol induces upregulation of the nerve growth factor receptor CD271 in human melanoma cells via nuclear factor-kappaB activation. Oncol Lett 10, 815-821 (2015).

More about Dr. Aurelio Lorico

Ranjana Mitra, PhD

Assistant Professor of Biomedical SciencesMolecular Biology and Biotechnology

Active research 

  • Factors effecting androgen receptor pathway and prostate cancer growth
  • Role of CYP3A4 in breast cancer growth
  • Role of lipid signaling in cancer circulating tumor cell detection and targeting
  • Role of HIV protease inhibitors in breast cancer growth
  • Pathways involved in non-small cell lung cancer growth

Bill Paull, PhD

Interim Chair, Department of Biomedical Sciences
Professor of Biomedical Sciences
Anatomy and Pathology

Recent publications

  • Edward J. Shahady and Willis K. Paull.  Chronic finger and hand pain in a middle-aged woman.  Consultant 2006:46 (13):1469-1472.
  • Heather C. Scott, Willis K. Paull and P. Kevin Rudeen. Effects of in utero ethanol exposure on the development of LHRH neurons in the mouse. Developmental Brain Research, 66:119-125, 1992.
  • Phelix, C.F., and Paull, W.K. Anterograde neuroanatomical tract tracing with central nervous system injections of immunoglobulin G: A light and electron microscopic evaluation. Brain Research Bulletin, 27:255-260, 1991.

Germana Rappa, MD, PhD

Associate Professor of Biomedical Sciences and Co-Director, Cancer Research Center

Active research

  • Experimental and Clinical Oncology

Recent publications

  • Setti, M. et al. Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth. Oncotarget 6, 31413-31427 (2015).
  • Rappa, G., Green, T.M., Karbanova, J., Corbeil, D. & Lorico, A. Tetraspanin CD9 determines invasiveness and tumorigenicity of human breast cancer cells. Oncotarget 6, 7970-7991 (2015).
  • Rappa, G., Fargeas, C.A., Le, T.T., Corbeil, D. & Lorico, A. Letter to the editor: An intriguing relationship between lipid droplets, cholesterol-binding protein CD133 and Wnt/beta-catenin signaling pathway in carcinogenesis. Stem Cells 33, 1366-1370 (2015).

Rouel Roque, MD

Professor of Biomedical Science
Cell Biology, Genetics, Anatomy

Active research

  • Molecular mechanisms of cardiac differentiation and regeneration
  • Cellular and molecular mechanisms and therapy of neurodegenerative diseases
  • Molecular mechanisms of cancer development and therapy (mechanisms of cisplatin resistance,
  • DNA vaccines for cancer therapy)

Recent Publications

  • Wang Z, Bartosh TJ, Ding M, Roque RS. (2014) MAPKs modulate RPE response to oxidative stress. (Proceedings of the 2013 International Conference on Biological and Medical Sciences, Phuket, Thailand, September 21-22, 2013). J. Medical and Bioengineering. 3(1):67-73. ISSN 2301-3796.
  • Bartosh TJ, Wang Z, Downey HF, Roque RS. (2014) Multipotent Progenitor Cells from the Adult Dog Heart Develop Into Organotypic Cultures of Functional Myocardium. (Proceedings of the International Conference on Advances in Science and Technology-2014, Pattaya, Thailand, February 15-16, 2014). International J. of Advances in Science & Technology, Science Publications, pp.206-211. ISSN 2348- 5426.


Stephanie Wragg, PhD

Assistant Dean for Curriculum and Assessment
Associate Professor of Biomedical Sciences
Biochemistry, Molecular Medicine and Genetics

Recent presentations and publications

  • What’s my style? A framework for enhancing leadership skills in medical education.
  • Burns CM  and Wragg S., IAMSE Annual Meeting. Leiden, NL 2016
  • What’s my style? A framework for enhancing leadership skills in medical education. Burns CM and Wragg S., IAMSE Annual Meeting, Cleveland, 2014
  • TBL oversight for continuous quality improvement and student acceptance. Burns CM and
  • Wragg S., Generalists in Medical Education. Philadelphia    2013
  • Lessons Learned During Curricular Reform: Things Can Only Get Better. Bradley, E., Burns, C.M., Michaelsen, V. and Wragg, S., AAMC CGEA Meeting, Cincinnati, 2013
  • “Lessons learned: Lessons from AAMC’s Enhancing Team Effectiveness Program “Retreat to Success”. Energizing Academic Medicine Teams”, Schrott, W.S., Madigovsky, W.and Wragg, S., AAMC WGEA/WGSA Conference, 2008
  • “Responding to the Need: New and Expanded Medical Schools”, El-Sawi, N., Steele, D.J. Wragg, S. and Wallach, P., AAMC Annual Meeting, Washington D.C.,2007
  • Li, S., Takeda, Y., Wragg, S., Dynan, W.S., (2003) Modification of the ionizing radiation response in living cells by an scFv against the DNA-dependent protein kinase, Nucleic Acids Research, 31(20):5848-57. http://nar.oupjournals.org/cgi/content/full/31/20/5848


Alan Greenberg, MD

Interim Chair, Department of Internal Medicine
Internal Medicine

Recent publications

  • Dawod Y, Greenberg A, Is IGRA testing using a dichotomous cutoff value accurate for contact tracing in TB investigations? Accepted Poster. American College of Physicians Annual Meeting, Boston MA, April 2015
  • Matta S., Greenberg A. Diarrhea with C. difficile-positive stool-trick or treat: Teachable Moment section. JAMA Internal Medicine. Published online September 14, 2015
  • Madison C, Greenberg A, A Pharmacist Led TB Infection Clinic in a County Health Department. Poster 186: American College of Clinical Pharmacy annual Meeting. San Francisco, 10/2015